Quinolines and derivatives
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Filtered Search Results
Ambeed AMBEED
5000849060 M-PEG3-AMINE 5G
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Ambeed AMBEED
5000849269 R -CHROMAN-4-AMINE HYDR 250MG
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Medchemexpress LLC Nα-Boc-Nω-nitro-D-arginine | 50913-12-7 | MFCD00038091 | 25g
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Afatinib impurity 7 (Boc-D-Arg(NO2)-OH) is an impurity of Afatinib (HY-10261)
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Selleck Chemical LLC RESIQUIMOD R-848-1G
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NC3234759 RESIQUIMOD R-848-1G
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Apexbio Technology LLC MI-2(Synonyms: Menin-MLL Inhibitor MI-2, MI2, MI 2, Menin inhibitor MI-2), 200mg, CAS: 1271738-62-5.
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MI-2 (CAS 1271738-62-5) is a small molecule inhibitor targeting the menin-MLL protein-protein interaction with an IC50 of 0 45 M The formation of menin-MLL fusion protein complexes resulting from chromosomal rearrangements plays an essential role in the pathogenesis of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) MI-2 selectively binds wild-type menin disrupting its interaction with MLL-fusion proteins such as MLL-AF9 thereby inhibiting cellular proliferation and colony formation in MLL-AF9-transduced mouse bone marrow cells MI-2 serves as a research tool in studies of leukemia biology and menin-associated oncogenesis
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Sigma Aldrich Fine Chemicals Biosciences Ethyl lactate 98 fCC fG25KG
Ethyl lactate is a major volatile flavor compound identified in Chinese Luzhou-flavor type liquor.
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Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 200mg
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NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways
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Apexbio Technology LLC CYT387 1056634-68-4 200mg
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CYT387 (CAS 1056634-68-4) is an aminopyrimidine derivative identified through high-throughput screening and optimized with structure-guided medicinal chemistry It functions as an inhibitor targeting Janus kinase family enzymes JAK1 JAK2 JAK3 and TYK2 with reported IC50 values of 11 nM 18 nM 155 nM and 17 nM respectively At concentrations between 500 1500 nM CYT387 selectively suppresses JAK2 signaling inhibits proliferation of JAK2-dependent hematopoietic cell lines and induces apoptosis with minimal effects on non-hematopoietic cells CYT387 is employed in experimental studies of JAK2-mediated signaling pathways and myeloproliferative neoplasms
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Apexbio Technology LLC Avasimibe 166518-60-1 200mg
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Avasimibe (CAS 166518-60-1) is an orally bioavailable inhibitor of acyl-coenzyme A cholesterol acyltransferase (ACAT) an enzyme involved in cholesterol esterification It exhibits potent inhibition with an IC50 of approximately 60 nM In cell-based studies avasimibe reduces intracellular cholesterol esters in a dose-dependent manner without elevating free cholesterol levels suggesting an advantageous safety profile Additionally avasimibe reduces synthesis and secretion of Apo B 100 a constituent of very low-density lipoprotein (VLDL) in HepG2 cells and increases bile acid synthesis in rat hepatocytes Beyond dyslipidemic modulation and anti-atherogenic activities it influences amyloid precursor protein (APP) trafficking reducing its maturation and subsequent amyloid-beta (A ) peptide generation providing avenues for Alzheimer s disease research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000772747 ACRIDINE-9-CARBOXALD 100MG
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Apexbio Technology LLC Tubastatin A HCl 1310693-92-5 200mg
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Tubastatin A HCl (CAS 1310693-92-5) is a selective inhibitor of histone deacetylase 6 (HDAC6) exhibiting an IC50 of approximately 15 nM HDAC6 is involved in diverse cellular processes including transcriptional regulation cell cycle progression and neuronal development dysregulated HDAC6 activity is implicated in conditions such as Alzheimer s disease and cancer In primary cortical neuron models Tubastatin A HCl at concentrations of 5 10 M confers protection against neuronal toxicity caused by homocysteic acid In HaCaT cells its HDAC6-specific inhibition prevents arsenite-induced association of Nrf2 mRNA with ribosomes and subsequent protein translation Tubastatin A HCl also enhances cell elasticity by modulating HDAC6-mediated cytoskeletal dynamics
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Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
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Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
- Elevates full-length SMN protein.
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- EC50 of 20 nM for SMN.
- IC50 of 6.3 μM for hERG.
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Medchemexpress LLC Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG
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Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG
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Sigma Aldrich Fine Chemicals Biosciences Ethyl 4 Ntrobenzoate Phar100MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
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![eMolecules 39061-97-7 | 4-Chloro-3-nitroquinoline | Synthonix | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 25g | 831794068](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000491361.jpg-250.jpg)
eMolecules 39061-97-7 | 4-Chloro-3-nitroquinoline | Synthonix | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 25g | 831794068
4-Chloro-3-nitroquinoline | Synthonix | 39061-97-7 | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 25g | 831794068
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